lots of和a lot of的意思基本一样，没有什么区别，一般是可以通用的，后面既可以加可数名词也可以加不可数名词。不过书面语用a lot of较多，口语用lots of较多。
a lot of例句
1.This type of shore bears a lot of weight.
这种类型的支撑可以承受很大重量。
2.The radiator gives out a lot of heat.
散热器释放出大量的热。
3.The project is still causing him a lot of problems.
这项工程现在仍然给他带来许多的麻烦。
4.This decision is likely to upset a lot of people.
这项决定很可能会使许多人不快。
5.The wind stirred up a lot of dust.
风吹起大量尘土。
lots of例句
1.She has lots of good ideas, but she has difficulty formulating them.
她有很多好的想法，但就是不善于表达。
2.We have lots of things in common besides music.
除了音乐，我们还有很多共通点。
3.There are lots of surprises in store for visitors to the gallery.
参观画展的人将会发现许多令他们惊奇的东西。
4.Her family and friends have given her lots of support.
家人和朋友给了她许多帮助。
5.Children need lots of love and affection.
孩子需要多多疼爱和关怀。
a lot of和a lot区别
1.a lot of重在于表示物品的数量，后可加可数名词也可以带不可数名词。如：
如:a lot of books很多书
a lot of milk很多牛奶
2.a lot 重在表示程度。如:
thanks a lot多谢
know a lot about China对中国了解很多